Product name: alpha-MSH
Synonyms: Melanotropin alpha,α-melanocyte stimulating hormone, Alpha-melanocyte stimulating hormone,Ac-SYSMEHFRWGKPV-amide,
CAS NO.: 581-05-5
Modifications: N-terminal acetylation,C-terminal amide
Counter ion: Trifluoacetate
Format: Lyophilized powder
Description: The neuropeptide alpha-Melanocyte Stimulating Hormone (α-MSH) is a thirteen amino acid peptide derived from endopeptidase cleavage of proopiomelanocortin hormone produced by the hypothalamus, monocytes, and retinal pigment epithelial cells (RPE). It is a neuropeptide that has an important role in metabolic and immune homeostasis. The neuropeptide suppresses inflammation mediated by both innate and adaptive immune responses . It suppresses NF-κB activation along with p38 MAPK phosphorylation [6–8]. The neuropeptide promotes the alternative activation of endotoxin-stimulated macrophages by inducing IL-10 and TGF-β production. In addition, it suppresses antigen presenting cells (APC) from activating effector T cells while promoting the APC to activate antigen-specific Treg cells.
Uniprot ID: P01189
Compound ID: 16133793
Usage: For Scientific Research Use Only, Not for Human Use.