Synonyms: γ-poly (glutamic acid)-L-phenylalanine methyl ester,
Molecular Weight: 1,000k
Phe Content: NLT10.0%
Loss on drying: NMT10.0%
Heavy metals: NMT20ppm
Format: Hygroscopic, white to slight yellow solid
Description: l-phenylalanine or l-leucine methyl esters were grafted to γ-PGA in the presence of the water-soluble carbodimide (WSC). These γ-PGA-Phe or γ-PGA-Leu copolymers with 30%–58% grafting degrees (determined by NMR) formed nanoparticles that were monodispersed in water because of their amphiphilic characteristics. In order to make self-assembled nanoparticles by the solvent exchange method, 10 mg/mL of γ-PGA-Phe was dissolved in DMSO that was then added to the same amount of distilled water. The particles were then dialysed to remove DMSO and then lyophilised. The average size of the γ-PGA-Phe NPs was approximately 200 nm, whereas γ-PGA-Leu NPs showed submicron order aggregations. Kim et al., 2009 found that the size of the γ-PGA-Phe formed monodispersed nanoparticles that can be easily controlled. By altering the NaCl concentration in distilled water, different NP sizes were obtained and ranged from 30 nm to 200 nm. Due to the ionisation of the carboxyl group found near to the γ-PGA surface, the nanoparticles showed highly negative charges, and the zeta potential was −25 mV.
Usage: For Scientific Research Use Only, Not for Human Use.