Thymosin α1

$ 360.0

Quantity: 50mg

In stock

SKU: 2214003 Category: Tag:

Description

Product name: Thymosinα1

Catalog#: 2214003

Organism: Human

Synonyms: Thymosin alpha 1,

CAS NO.: 62304-98-7

Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn

Modifications: N-terminal acetylation,

M.W: 3108.28

M.F.: C129H215N33O55

Purity: 95%

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Thymosin alpha 1 (Tα1), a 28-amino acid peptide, was first described and characterized from calf thymuses in 1977. This peptide can enhance T-cell, dendritic cell (DC) and antibody responses, modulate cytokines and chemokines production and block steroid-induced apoptosis of thymocytes. Due to its pleiotropic biological activities, Tα1 has gained increasing interest in recent years and has been used for the treatment of various diseases in clinic. Increasing evidence showed invariant NKT cells (iNKT cell) are an attractive candidate for cancer immunotherapy, but its role in colorectal cancer treatment was still unclear. Here we reported iNKT cells exerted moderate cytotoxic effect against colorectal cancer cells (CRC cells) with the stimulation of α-Galcer, and the mutual recognition between CRC and iNKT cells could be greatly enhanced by Thymosinα1 (TA), which resulted in stronger killing efficiency both in vitro and in vivo.

Uniprot ID: P06454

 

Usage: For Scientific Research Use Only, Not for Human Use.