Dihexa

Description

Product name: Dihexa

Catalog#: 1240109

Synonyms: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide (dihexa),

CAS NO.: 1401708-83-5

Sequence: Hexanoic-Tyr-Ile-Ahx

Modifications: N-terminal Hexanoyl, C-terminal amide,

M.W: 504.66

M.F.: C27H44N4O5

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: The results of the study described here indicated that N-terminal modifications, and to a lesser extent C-terminal modifications, could improve the metabolic stability of Nle1-AngIV–derived tri- and tetrapeptides while preserving procognitive and synaptogenic activities. Expanding on these data, additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N-hexanoic-Tyr-Ile-(6) aminohexanoic amide (dihexa), a potent cognitive-enhancing molecule that proved to be very stable, capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, slowly cleared from the blood compartment, and sufficiently BBB-permeable.

Uniprot ID:

 

 Notice : Only for research purpose, not for human and veterinary use .  This product is not available for US.