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Peptides as therapeutics

Therapeutic peptides are described as naturally occurring short amino acid monomer chains, shorter than 100 amino acids, and they act by binding to specific cell surface receptors, where they trigger intracellular pathways. They have been shown to possess desirable pharmacological…
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Neoglycolipids for Prolonging the Effects of Peptides: Self-Assembling Glucagon-like Peptide 1 Analogues with Albumin Binding Properties and Potent in Vivo Efficacy

Novel principles for optimizing the properties of peptide-based drugs are needed in order to leverage their full pharmacological potential. We present the design, synthesis, and evaluation of a library of neoglycolipidated glucagon-like peptide 1 (GLP-1) analogues, which are valuable drug…
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