SFLLRN

Description

Product name: SFLLRN

Catalog#: 1809067

Synonyms: PAR1 agonist peptide, PAR1 agonist SFLLRN-NH2, Thrombin receptor activation peptide (SFLLRN),

CAS NO.:

Sequence: Ser-Phe-Leu-Leu-Arg-Asn-NH2

M.W: 747.89

M.F.: C34H57N11O8

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Protease-activated receptor-1 (PAR1) is activated by the cleavage of the extracellular N-terminal domain by proteases such as thrombin and plasmin. This cleavage releases a tethered ligand (SFLLRN) that activates the receptor and initiates a signaling cascade through Gαq/11, Gαi/o, or Gα12/13 G-proteins. Free SFLLRN activates Protease-activated receptor-1 (PAR1) independent of receptor cleavage and has been used to probe PAR1 function in various cells and tissues.  SFLLRN-NH2-induced increases in astrocytic and neuronal calcium signals are blocked when the cells are pretreated with the glial metabolic blocker, fluorocitrate. Protease-activated receptor 1 agonist SFLLRN induced latent TGFβ1 activation and Smad3 phosphorylation in human gingival fibroblasts.

Compound ID:

 

Usage: For Scientific Research Use Only, Not for Human Use.