10-deacetylbaccatin III

Description

Product name: 10-deacetylbaccatin III

Synonym: 10-DAB III; 10-Deacetylbaccatin III

Catalog #: BP0011

Purity: 98%

CAS No.: 32981-86-5

Molecular Formula: C₂₉H₃₆O₁₀

Molecular Weight: 544.597

Botanical Source: Taxus baccata; Taxus mairei SY Hu.

Analysis Method: HPLC-DAD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Description:10-Deacetyl Baccatin III or 10-DAB III is a crucial intermediate for Paclitaxel & Docitaxel, two of the best anti-cancer drugs ever invented. Natural Paclitaxel was once isolated in very small quantities from the Yew tree (Taxus species) resulting in the large-scale destruction of its natural habitat. By extracting the pre-cursor 10-DAB III in large quantites from the Taxus baccata leaf, many subsequent semi-syntheses can be carried out. The esterification of 10-DAB III also causes an enhancement in the kinetics, and in the pharmacological profile of these important chemo-therapeutic agents.