1-Methyl-L-4,5-dihydroorotic acid

$ 380.0

Quantity: 10Gram

In stock

SKU: 8311013 Category:


Product name: 1-Methyl-L-4,5-dihydroorotic acid


Catalog #: 8311013

Purity: 97%

CAS No.: 103365-69-1

Molecular Formula: C6H8N2O4

Molecular Weight: 172.14

Compound ID: 13507105

Description: A series of thyrotropin-releasing hormone (TRH) analogues in which the pyroglutamic acid residue was replaced by (S)-4,5-dihydroorotic acid (Dio-OH) and the related derivatives were prepared. Their central nervous system actions based on spontaneous locomotor activity, antagonistic effect on reserpine-induced hypothermia, and antagonistic effect on pentobarbital anesthesia were evaluated and the structure-activity relationships are discussed. Of these, (1-methyl-(S)-4,5-dihydroorotyl)-L-histidyl-L-prolinamide showed the most potent activities, which were 30-90 times greater than those of TRH. Moreover, the thyrotropin-releasing activity was about 50 times weaker than that of TRH, and compound TA-0910 was selected as a potent candidate.

API: Taltirelin