Product name: 1-Methyl-L-4,5-dihydroorotic acid
Synonym: (S)-1-METHYL-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIc acid,
Catalog #: 8311013
CAS No.: 103365-69-1
Molecular Formula: C6H8N2O4
Molecular Weight: 172.14
Compound ID: 13507105
Description: A series of thyrotropin-releasing hormone (TRH) analogues in which the pyroglutamic acid residue was replaced by (S)-4,5-dihydroorotic acid (Dio-OH) and the related derivatives were prepared. Their central nervous system actions based on spontaneous locomotor activity, antagonistic effect on reserpine-induced hypothermia, and antagonistic effect on pentobarbital anesthesia were evaluated and the structure-activity relationships are discussed. Of these, (1-methyl-(S)-4,5-dihydroorotyl)-L-histidyl-L-prolinamide showed the most potent activities, which were 30-90 times greater than those of TRH. Moreover, the thyrotropin-releasing activity was about 50 times weaker than that of TRH, and compound TA-0910 was selected as a potent candidate.