7-beta-Hydroxylathyrol

Description

Product name: 7-beta-Hydroxylathyrol

Synonym:7-Hydroxylathyrol

Catalog #: BP0097

Purity: 98%

CAS No.: 34208-98-5

Molecular Formula: C₂₀H₃₀O₅

Molecular Weight: 350.455

Botanical Source: Euphorbia lathyris

Analysis Method: HPLC-DAD or/and HPLC-ELSD

Identification Method: Mass, NMR

The purity(assay) of  90%, 95% and 98% is available for food, nutrition and cosmetics request, except for R&D and reference standard.

Description:

Reference standards.

 

References:

Journal of Molecular Catalysis B: Enzymatic, 2017:S1381117717300279.

Regioselective hydroxylation of lathyrane diterpenoids biocatalyzed by microorganisms and its application in integrated synthesis.

METHODS AND RESULTS:

The regioselective oxidation of three lathyrane diterpenoids (lathyrol, 1; 7-beta-Hydroxylathyrol, 2; and Euphorbia factor L3, 3) catalyzed by the fungi Mortierella ramanniana CGMCC 3.03413, Mucor circinelloides CICC 40242, and the actinomycete Nocardia iowensis sp. nov. NRRL 5646 was investigated. Ten new metabolites (4–13) including two unprecedented cyclopropane-rearranged products (4 and 5) have been obtained. Metabolites (6, 10 and 11) were further converted chemically to eight acylated derivatives (6a, 10a–10f and 11a).

CONCLUSIONS:

The structures of all compounds were elucidated on the basis of extensive NMR and MS data analyses. All the metabolites and enzyme-chemical products were evaluated for their cytotoxicities against three human cancer cell lines as well as their multidrug resistance (MDR) reversing effects in adriamycin (ADM)-resistant human MCF-7 breast cancer cells (MCF-7/ADM).