Quantity: 1000 MG
Product name: 7-beta-Hydroxylathyrol
Catalog #: BP0097
CAS No.: 34208-98-5
Molecular Formula: C20H30O5
Molecular Weight: 350.455
Botanical Source: Euphorbia lathyris
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
The purity(assay) of 90%, 95% and 98% is available for food, nutrition and cosmetics request, except for R&D and reference standard.
Journal of Molecular Catalysis B: Enzymatic, 2017:S1381117717300279.
Regioselective hydroxylation of lathyrane diterpenoids biocatalyzed by microorganisms and its application in integrated synthesis.
METHODS AND RESULTS:
The regioselective oxidation of three lathyrane diterpenoids (lathyrol, 1; 7-beta-Hydroxylathyrol, 2; and Euphorbia factor L3, 3) catalyzed by the fungi Mortierella ramanniana CGMCC 3.03413, Mucor circinelloides CICC 40242, and the actinomycete Nocardia iowensis sp. nov. NRRL 5646 was investigated. Ten new metabolites (4–13) including two unprecedented cyclopropane-rearranged products (4 and 5) have been obtained. Metabolites (6, 10 and 11) were further converted chemically to eight acylated derivatives (6a, 10a–10f and 11a).
The structures of all compounds were elucidated on the basis of extensive NMR and MS data analyses. All the metabolites and enzyme-chemical products were evaluated for their cytotoxicities against three human cancer cell lines as well as their multidrug resistance (MDR) reversing effects in adriamycin (ADM)-resistant human MCF-7 breast cancer cells (MCF-7/ADM).