AGES

Description

Product name: AGES

Catalog#: 2214105

Organism: Human

Synonyms: Tetrapeptide AGES

CAS NO.:

Sequence: Ac-Ser-Asp-Lys-Pro

Modifications:

M.W: 362.34

M.F.: C13H22N4O8

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: TB4 specific C-terminal tetrapeptide, AGES, increases embryonic cardiac cell migration and myocyte beating in culture, and improves adult mammalian heart function following ischemia. Investigating the molecular background and mechanism we discovered systemic injection of AGES enhances early myocyte survival by activating Akt-mediated signaling mechanisms, increases coronary vessel growth and inhibits inflammation in mice and pigs. Biodistribution analyses revealed cardiomyocytes uptake AGES efficiently in vitro and in vivo projecting a potential independent clinical utilization for the tetrapeptide. Our comprehensive domain investigations also suggest, preservation and/or restoration of cardiomyocyte communication is a target of TB4 and AGES, and critical to improve post-ischemic heart function in pigs. AGES as a novel, systemically applicable drug candidate to aid cardiac infarction in adult mammals.

Uniprot ID:

 

Usage: For Scientific Research Use Only, Not for Human Use.