Allatotropin

Description

Product name: Allatotropin

Catalog#: 1238001

Organism: Triatomid bug

Synonyms: Allatotropin (AT),Rhopr-AT,GFKNVQLSTARGF-amide,

CAS NO.: 120928-88-3

Sequence: Gly-Phe-Lys-Asn-Val-Glu-Met-Met-Thr-Ala-Arg-Gly-Phe-NH2

Modifications: C-terminal amide,

M.W: 1486.78

M.F.: C65H103N19O17S2

Purity: 95%

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Allatotropin (AT), a neuropeptide isolated on the basis of its activity stimulating juvenile hormone synthesis in the lepidoteran Manduca sexta , has also proved to be multifunctional, acting in different insect species as myoregulator and cardioaccelerator. Allatotropin (AT),as a cardioacceleratory and a myostimulatory peptide at the level of the anterior midgut. The peptide induced the increase of the rate of contractions of the anterior midgut and the aorta in a wide range of concentrations. The cardioacceleratory effect of AT was dependent on the feeding state of the insects and on the presence of serotonin. The response showed the existence of a differential behavior between sexes, inducing a higher increase on the frequency of contractions, as well as, the width of the aorta in males than in females. Finally, our results suggest that AT interacts with serotonin to facilitate the circulation of haemolymph during post-prandial diuresis. Allatotropin, the neuropeptide that promotes Juvenile hormone (JH) biosynthesis in the corpora allata (CA).

Uniprot ID: P85825

 

Usage: For Scientific Research Use Only, Not for Human Use.