alpha-MSH

$ 250.0

Quantity: 10 MG

In stock

Categories: ,

Description

Product name: alpha-MSH

Catalog#: 1284001

Organism: Human

Synonyms: Melanotropin alpha,α-melanocyte stimulating hormone, Alpha-melanocyte stimulating hormone,Ac-SYSMEHFRWGKPV-amide,

CAS NO.: 581-05-5

Sequence: Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

Modifications: N-terminal acetylation,C-terminal amide

M.W: 1664.91

M.F.: C77H109N21O19S

Purity: 95%

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: The neuropeptide alpha-Melanocyte Stimulating Hormone (α-MSH) is a thirteen amino acid peptide derived from endopeptidase cleavage of proopiomelanocortin hormone produced by the hypothalamus, monocytes, and retinal pigment epithelial cells (RPE). It is a neuropeptide that has an important role in metabolic and immune homeostasis. The neuropeptide suppresses inflammation mediated by both innate and adaptive immune responses . It suppresses NF-κB activation along with p38 MAPK phosphorylation [6–8]. The neuropeptide promotes the alternative activation of endotoxin-stimulated macrophages by inducing IL-10 and TGF-β production. In addition, it suppresses antigen presenting cells (APC) from activating effector T cells while promoting the APC to activate antigen-specific Treg cells.

Uniprot ID: P01189

Compound ID: 16133793

 

Usage: For Scientific Research Use Only, Not for Human Use.