B cell epitope PPGMRPP

$ 450.0

Quantity: 50 MG

In stock (can be backordered)

SKU: 1401029 Categories: ,

Description

Product name: B cell epitope PPGMRPP

Catalog#: 1401029

Organism:

Synonyms:

CAS NO.:

Sequence: PPGMRPP

Modifications:

M.W:750.91

M.F.:C33H54N10O8S1

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: The main B cell epitope, PPGMRPP, of the Sm autoantigen against which the majority of antibodies in patients with systemic lupus erythematosus is directed, was coupled to the Lys-N(epsilon)H(2) groups of the carrier in four copies and the resulting conjugate Palm-SOC(4)-II-Sm(4) was subjected to animal immunizations without utilizing any adjuvant. The induced immune response was comparable with that produced when Ac-SOC(4)-II-Sm(4) was administered in animals following the conventional immunization protocol of complete/incomplete Freund’s adjuvant. High titers of anti-Palm-SOC(4)-II-Sm(4) antibodies were generated, which recognize the priming immunogenic conjugate, as well as reconstituted Sm mimics but not the carrier alone.

Uniprot ID:

 

Usage: For Scientific Research Use Only, Not for Human Use.