$ 800.0
Quantity: 50 MG
Available on backorder
Description
Product name: CDIP-2
Catalog#: 1809045
Synonyms: CCL13(19-37),
CAS NO.:
Sequence: KISLQRLKSYVITTSRCPQ
Modifications:
M.W:2220.24
M.F.:C97H169N29O28S
Purity: 95% by HPLC
Counter ion: Trifluoroacetate
Format: Lyophilized powder
Description: CDIP-2, a chemokine derived peptide, corresponds to residues 19–37 of CCL13, reduced in vitro chemotaxis and decreased cellular infiltration in a murine model of allergic airway inflammation.CDIP-2 reduces chemotaxis towards CCL11 and CCL3 and calcium fluxes in bone marrow-derived murine eosinophils. Additionally, CDIP-2 induces the internalization of CCR1, CCR2 and CCR3 receptors, although it does not evoke G protein dissociation, chemotaxis orMAPK activation.Finally, in a severe murinemodel of allergic airway inflammation, CDIP-2 treatment decreased the expression of Th2 cytokines and chemokine receptors related to the inflammatory process.
UniProt ID:
Usage: For Scientific Research Use Only, Not for Human Use.
