Cyclo(RGDf-N(Me)V-)

Description

 

Product name: Cyclo(RGDf-N(Me)V-)

Catalog#: 1806029

Synonyms:

CAS NO.:

Sequence:  c(Arg-Gly-Asp-D-Phe-N-Me-Val)

M.W: C27H40N8O7

M.F.: 588.66

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: The αVβ3 integrin receptor plays an important role in human tumor metastasis and tumor-induced angiogenesis. The in vivo inhibition of this receptor by antibodies or by cyclic peptides containing the RGD sequence may in the future be used to selectively suppress these diseases. Here we investigate the influence of N-methylation of the active and selective αVβ3 antagonist cyclo(RGDfV) (L1) on biological activity. Cyclo(RGDf-N(Me)V-) (P5) was found to be even more active than L1 and is one of the most active and selective compounds in inhibiting vitronectin binding to the αVβ3 integrin.

Compound ID:

 

Usage: For Scientific Research Use Only, Not for Human Use.