c[YpwFG]

Description

Product name: c[YpwFG]

Catalog#: 1805022

Synonyms: cyclic endomorphin-1 ,

CAS NO.:

Sequence: c[Tyr-D-Pro-D-Trp-Phe-Gly]

M.W: 650.72

M.F.: C36H38N6O6

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Endomorphins, the endogenous ligands of the µ-opioid receptor, are attractive candidates for opioid-based pain-relieving agents. These tetrapeptides, with their remarkable affinity for the µ-opioid receptor, display favorable antinociceptive activity when injected directly into the brain of experimental animals. However, the application of endomorphins as clinical analgesics has been impeded by their instability in body fluids and inability to reach the brain after systemic administration. Among numerous modifications of the endomorphin structure aimed at improving their pharmacological properties, cyclization can be viewed as an interesting option. c[YpwFG] displays sufficient metabolic stability to be effective after peripheral administration and demonstrates the therapeutic potential of endomorphin derivatives as novel analgesic agents to control visceral pain.

Uniprot ID:

 

Usage: For Scientific Research Use Only, Not for Human Use.