Quantity: 50 MG
Available on backorder
Product name: d-peptide D3
Synonyms: d-enantiomeric peptide D3,
Purity: 95% by HPLC
Counter ion: Trifluoroacetate
Format: Lyophilized powder
Description: The d-peptide D3 (amino acid sequence RPRTRLHTHRNR), β-sheet breaking d-enantiomeric dipeptide was reported to selectively target Aβ soluble oligomers, was identified during a mirror image phage display selection using d-enantiomeric Aβ42 as a target under conditions where monomeric or small oligomeric Aβ42 species can be expected to be the dominating species. The compound was orally bioavailable, reduced the plaque load in AD transgenic mice, and improved their cognitive performance. D3 precipitates toxic Aβ species and converts them into nonamyloidogenic, nonfibrillar, and nontoxic aggregates without increasing the concentration of monomeric Aβ. Thus, D3 exerts an interesting and novel mechanism of action that abolishes toxic Aβ oligomers and thereby supports their decisive role in AD development and progression.
Usage: For Scientific Research Use Only, Not for Human Use.