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Quantity: 1 G

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SKU: 1801029 Categories: ,


Product name: Dipeptide-2

Catalog#: 1801029

Synonyms: L-valyl-L-tryptophan (VW), VW,Eyeliss,N-Valyltryptophan, N-L-Valyl-L-tryptophan,

CAS NO.: 24587-37-9

Sequence: Val-Trp

M.W: 303.36

M.F.: C16H21N3O3

Purity: 95% by HPLC

Counter ion: Acetate

Format: Lyophilized powder

Description: Valine-tryptophan (VW) reduces blood pressure when delivered orally. The peptide VW has been marketed as dipeptide-2 (or Dipeptide VW) by Sederma. Of twelve dipeptides tested, only the Trp containing peptides Val-Trp and its reverse peptide Trp-Val showed a xanthine oxidase (XO) inhibitory activity. Studies with Val and Trp revealed that XO inhibition was mainly attributed to the Trp residue.  This dipeptide VW shows an interesting anti-angiotensin converting enzyme (anti-ACE) activity. In contrast, the lactotripeptides Ile-Pro-Pro and Val-Pro-Pro, which were widely used as ingredients for hypotensive food, showed a slight selectivity for the N-domain. Hence, tryptophan containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain.

Compound ID: 168182


Usage: For Scientific Research Use Only, Not for Human Use.