GSB-106

$ 800.0

Quantity: 50mg

In stock

SKU: 1805032 Category: Tag:

Description

Product name: GSB-106

Catalog#: 1805032

Synonyms: bis-(N-monosuccinyl-l-seryl-l-lysine) hexamethylenediamide (GSB-106),

M.W: 746.85

M.F.: C32H58N8O12

Purity: 95%

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: A low-molecular-weight mimetic GSB-106, which is a substituted dimeric dipeptide bis(N-monosuccinyl-L-seryl-L-lysine)hexamethylenediamide, was designed and synthesized based on the BDNF fourth loop structure at the V.V. Zakusov Institute of Pharmacology (RAMS). In vivo experiments revealed significant antidepressant properties of GSB-106 in doses of 0.1-10 mg/kg (intraperitoneally and orally). Effects of GSB-106 on hippocampal neurogenesis were studied in mice subjected to chronic predator stress. Proliferative activity in the subgranular zone of the dental gyrus was assessed immunohistochemically by Ki-67 expression (a marker of dividing cells). It was found that GSB-106 (10 mg/kg, intraperitoneally, 5 days) completely prevents neurogenesis disturbances in stressed mice. These findings suggest that GSB-106 is a promising candidate for the development of antidepressant agents with BDNF-like mechanism of action.

 

Usage: For Scientific Research Use Only, Not for Human Use.