Product name: Huntingtin 1–17
Synonyms: N17, Htt17, MATLEKLMKAFESLKSF,
Counter ion: Trifluoacetate
Format: Lyophilized powder
Description: Huntingtin 1–17 has been shown to be involved in huntingtin membrane interactions when at the same time this domain is known to interact with itself as well as with polyglutamines. Importantly, the presence of huntingtin 1–17 enhances polyglutamine aggregation, and polyglutamine has been shown to interact with itself, huntingtin 1–17 as well as with other proteins. The Htt17 segment of the first exon is of fundamental importance. It acts as a membrane anchor that modulates the localization of huntingtin to specific membrane-containing organelles of the cell such as the endoplasmic reticulum, the mitochondria, and the Golgi. Htt17 also acts as a nuclear export sequence that regulates the localization of huntingtin between the cytoplasm and the nucleus. It interacts with the TRiC chaperonin to suppress the aggregation of huntingtin. And it can undergo posttranslational modifications such as SUMOylation and phosphorylation that modulate the toxicity, clearance, localization, and function of huntingtin. This small segment also accelerates the fibrillation kinetics and changes the nucleation and the oligomer structures of the amyloidogenic QN segment. These observations indicate that Htt17 is crucial to huntingtin physiological and pathological functions.
Usage: For Scientific Research Use Only, Not for Human Use.