L-homotyrosine HBr

$ 600.0

Quantity: 10Gram

In stock

SKU: 8207307 Category:


Product name: L-homotyrosine HBr

Synonym: Homo-L-Tyrosine.HBr, (S)-2-Amino-4-(4-hydroxyphenyl)butanoic acid hydrobromide, L-Homotyrosine hydrobromide, L-Homotyrosine HBr, Homo-L-tyrosine Hydrobromide, Homotyrosine (Hty) ,

Catalog #: 8207307

Purity: 97%

CAS No.: 141899-12-9

Molecular Formula: C10H14BrNO3

Molecular Weight: 276.13

Compound ID: 45357976

Description: L-homotyrosine is a component of the peptide pneumocandin core. Lyngbyastatin 4 (1), a new depsipeptide containing the unusual amino acid homotyrosine and a 3-amino-6-hydroxy-2-piperidone (Ahp) residue, was isolated from a collection of the marine cyanobacterium Lyngbya confervoides off the Florida Atlantic coast. Its gross structure was determined by NMR spectroscopy, and the configurations of asymmetric centers were assigned after chiral HPLC analysis of hydrolysis products. Lyngbyastatin 4 (1) is an analogue of the sea hare isolate dolastatin 13 and several marine cyanobacterial metabolites, further supporting the notion that many of the dolastatins are of cyanobacterial origin. Lyngbyastatin 4 (1) selectively inhibits elastase and chymotrypsin in vitro over other serine proteases with IC50 values of 0.03 and 0.30 microM, respectively.