p53pAnt

Description

Product name: p53pAnt

Catalog#: 1807028

Synonyms:

CAS NO.:

Sequence: GSRAHSSHLKSKKGQSTSRHKKWKMRRNQFWVKVQRG

M.W:4434.09

M.F.:C192H315N71O49S1

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: The p53pAnt peptide comprises the C-terminal region of the protein p53, as bioactive sequence, fused by its carboxyl terminal extreme to the cell penetrating peptide Penetratin, as transporter sequence, (GSRAHSSHLKSKKGQSTSRHKKWKMRRNQFWVKVQRG). It has been shown that this peptide selectively induces apoptosis in cancer cells with mutated or overexpressed p53 through p53-dependent processes. The anticancer peptide has been tested in vitro in different cell types, such as colon cancer cells, breast cancer, lung and lymphoma. Furthermore, it has been reported to selectively produce necrosis in prostate cancer cells and that it is able to selectively induce cell death by apoptosis in vivo, in a model of brain tumor (glioma) in rats.

Compound ID:

 

Usage: For Scientific Research Use Only, Not for Human Use.