Product name: Pleurocidin (Ple)
Organism: Winter flounder
Modifications: C-terminal amide,
Counter ion: Trifluoacetate
Format: Lyophilized powder
Description: Pleurocidin (Ple) is one of the most well-known not only as a α-helical cationic antibacterial, but also as surface-active peptides derived from the skin mucous of the winter flounder (Pleuronectes americanus). In vitro study in trout macrophages has demonstrated that PLE peptide is able to trigger the expression of immune-relevant genes encoding IL-1β and cyclooxygenase-2, which are critical modulators in activating innate immunity. PLE peptide also effectively stimulates mast cells to produce proinflammatory chemokines, monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β). Such PLE-induced chemokines are capable of activating and recruiting immune cells, including neutrophils, monocytes, macrophages and T-lymphocytes, to the sites of tissue injury, infection and inflammation, thereby contributing to subsequent innate and adaptive immune responses. The immunomodulatory activities mentioned above therefore make PLE peptide an attractive agent to be explored as an adjuvant in animal vaccine.
Uniprot ID: P81941
Usage: For Scientific Research Use Only, Not for Human Use.