$ 300.0
Quantity:10mg
In stock
Description
Product name: Rotigaptide
Catalog#: 1808224
Synonyms: ZP 123,ZP123,ZP123 peptide
Sequence: Ac-D-Tyr-D-Pro-D-Hyp-Gly-D-Ala-Gly-NH2
M.W: C28H39N7O9
M.F.: 617.65
Purity: 95%
Format: White powder
Description: To address cardiac arrhythmia, hexa-peptides such as AAP10 derived from bovine atria and a stable analogue ZP123, now termed rotigaptide, have been developed to modify gap junctional channel properties and intercellular communication . Rotigaptide promoted electrical coupling between ventricular myocytes without changing membrane conductance . The peptide attenuated gap junction closure and preserved intercellular coupling during acidosis . Most importantly, rotigaptide reduced the inducibility of re-entry ventricular tachycardia during acute ischaemia in dogs . Indeed, these properties suggest that rotigaptide could be a prototype of a new class of antiarrhythmic drug.
Compound ID: 9938933
Usage: For Scientific Research Use Only, Not for Human Use.
