$ 1,350.0

Quantity: 5 MG

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SKU: 1806027 Categories: ,


Product name: ST1646

Catalog#: 1806027



Sequence: cyclo-(Arg-Gly-Asp-lactam)

M.W: C22H34N8O7

M.F.: 522.56

Quantity: 5mg

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: The replacement of the d-Phe-Val dipeptide in the lead structure cyclo-(RGDfV) with such azabicycloalkane scaffolds showing different reverse-turn mimetic properties constrains the RGD sequences into different conformations and provides the required activity and selectivity for integrin antagonism. This library was found to contain specific high-affinity ligands for avb3 and avb5 integrins, which are presently under evaluation as very promising anti-angiogenic drugs.ST1646 showed the highest affinity for aVb3 and avb5, inhibiting echistatin binding to aVb3 and aVb5 with IC50 values of 3.7 0.6 and 1.39 0.2 nm,respectively.

Compound ID:


Usage: For Scientific Research Use Only, Not for Human Use.