$ 1,350.0
Quantity: 5 MG
Available on backorder
Description
Product name: ST1646
Catalog#: 1806027
Synonyms:
CAS NO.:
Sequence: cyclo-(Arg-Gly-Asp-lactam)
M.W: C22H34N8O7
M.F.: 522.56
Quantity: 5mg
Purity: 95% by HPLC
Counter ion: Trifluoacetate
Format: Lyophilized powder
Description: The replacement of the d-Phe-Val dipeptide in the lead structure cyclo-(RGDfV) with such azabicycloalkane scaffolds showing different reverse-turn mimetic properties constrains the RGD sequences into different conformations and provides the required activity and selectivity for integrin antagonism. This library was found to contain specific high-affinity ligands for avb3 and avb5 integrins, which are presently under evaluation as very promising anti-angiogenic drugs.ST1646 showed the highest affinity for aVb3 and avb5, inhibiting echistatin binding to aVb3 and aVb5 with IC50 values of 3.7 0.6 and 1.39 0.2 nm,respectively.
Compound ID:
Usage: For Scientific Research Use Only, Not for Human Use.
