iRGD

Description

Product name: iRGD

Catalog#: 1806028

Synonyms: CRGDKGPDC

Sequence: Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys

Modifications: disulfide,

M.W: 948.04

M.F.: C35H57N13O14S2

Purity: 95%

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Tumor-specific tissue-penetrating peptides deliver drugs into extravascular tumor tissue by increasing tumor vascular permeability through interaction with neuropilin (NRP). Here, we report that a prototypic tumor-penetrating peptide iRGD (amino acid sequence: CRGDKGPDC) potently inhibits spontaneous metastasis in mice. The antimetastatic effect was mediated by the NRP-binding RXXK peptide motif (CendR motif), and not by the integrin-binding RGD motif. iRGD inhibited migration of tumor cells and caused chemorepulsion in vitro in a CendR- and NRP-1-dependent manner. The peptide induced dramatic collapse of cellular processes and partial cell detachment, resulting in the repellent activity. These effects were prominently displayed when the cells were seeded on fibronectin, suggesting a role of CendR in functional regulation of integrins. The antimetastatic activity of iRGD may provide a significant additional benefit when this peptide is used for drug delivery to tumors.

 

Usage: For Scientific Research Use Only, Not for Human Use.