$ 150.0
Quantity: 50 MG
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Description
Product name: Livagen
Catalog#: 1808217
Synonyms: Lys-Glu-Asp-Ala
CAS NO.:
Sequence: Lys-Glu-Asp-Ala
M.W: C18H31N5O9
M.F.: 461.47
Purity: 95% by HPLC
Format: White powder
Description: It is stated that Livagen (Lys-Glu-Asp-Ala) is a weakly hydrolyzed peptide. Peptide hydrolases of small intestine do not hydrolyze Livagen even to a small extent. Under in vitro conditions Livagen reduces glycil-L-leucinedipeptidase activity in small intestine by 50%.Livagen induced activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin, and release of genes repressed due to age-related condensation of euchromatic regions in chromosomes. Our results indicate that Livagen causes de-heterochromatinization (activation) of chromatin, which is realized via modification of heterochromatin and heterochromatinized regions in chromosomes from old people.Livagen proved to be more efficient also as compared to well-known peptidase inhibitors such as puromycin, leupeptin, and D-PAM. The dose-inhibitory effect curves for Livagen and Epitalon were plotted; their IC50 equaled 20 and 500 microM, respectively.
Compound ID:
Usage: For Scientific Research Use Only, Not for Human Use.
