d-peptide D3

Description

Product name: d-peptide D3

Catalog#: 1809049

Synonyms: d-enantiomeric peptide D3,

CAS NO.:

Sequence: rprtrlhthrnr

Modifications:

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M.F.:

Purity: 95% by HPLC

Counter ion: Trifluoroacetate

Format: Lyophilized powder

Description: The d-peptide D3 (amino acid sequence RPRTRLHTHRNR), β-sheet breaking d-enantiomeric dipeptide was reported to selectively target Aβ soluble oligomers, was identified during a mirror image phage display selection using d-enantiomeric Aβ42 as a target under conditions where monomeric or small oligomeric Aβ42 species can be expected to be the dominating species. The compound was orally bioavailable, reduced the plaque load in AD transgenic mice, and improved their cognitive performance. D3 precipitates toxic Aβ species and converts them into nonamyloidogenic, nonfibrillar, and nontoxic aggregates without increasing the concentration of monomeric Aβ. Thus, D3 exerts an interesting and novel mechanism of action that abolishes toxic Aβ oligomers and thereby supports their decisive role in AD development and progression.

UniProt ID:

 

Usage: For Scientific Research Use Only, Not for Human Use.