$ 1,585.0
Quantity: 1 g
In stock
Description
Product name: Mu-Conotoxin
Catalog#: 1801201-1
Synonyms: μ-Conotoxin Cn IIIC; XEP-018
Sequence:
CAS： 936616-33-0
M.W: 2375.7
M.F.: C92H139N35O28S6
Purity : 98.5%
Active peptide assay ： 50ppm
Solubility: Water
pH: 5-7
Format: Clear cololess solution
Description: Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin blocks both voltage-gated sodium channels and nicotinic acetylcholine receptor (nAChR). Inhibits the skeletal muscle rNav1.4/SCN4A (IC50=1.3 nM) and the brain rNav1.2/SCN2A in a long-lasting manner. A low inhibition is also observed on neuronal mNav1.6/SCN8A and mNav1.7/SCN9A. Modestly blocks nAChR alpha-3/beta-2 subtype (IC50=450 nM) (partially reversible) and, to a lesser extent, alpha-7 and alpha-4/beta-2 subtypes (reversible). In vitro, decreases twitch tension in mouse hemidiaphragms (IC50=150 nM), and displays a high blocking effect in mouse extensor digitorum longus muscles (IC50=46 nM).
Usage: For Scientific Research Use Only, Not for Human Use.
