$ 600.0
Quantity: 1mg
In stock
Description
Product name: Cyclic peptide [R4W4]
Catalog#: 1399031
Synonyms: cyclo(RRRRWWWW),
Sequence: cyclo(Arg-Arg-Arg-Arg-Trp-Trp-Trp-Trp)
Modifications: head-to-tail cyclization,
M.W: 1369.60
M.F.: C68H88N24O8
Purity: 95%
Counter ion: Trifluoacetate
Format: Lyophilized powder
Description: Antimicrobial peptides, a major class of antibacterial agents, share amphiphilicity and cationic structural properties with cell-penetrating peptides (CPPs). Herein, several amphiphilic cyclic CPPs and their analogues were synthesized and exhibited potent antibacterial activities against multidrug-resistant pathogens. Among all the peptides, cyclic peptide [R4W4] showed the most potent antibacterial activity against methicillin-resistant Staphylococcus aureus [MRSA, exhibiting a minimal inhibitory concentration (MIC) of 2.67 μg/mL]. Cyclic [R4W4] and the linear counterpart R4W4 exhibited MIC values of 42.8 and 21.7 μg/mL, respectively, against Pseudomonas aeruginosa.
Usage: For Scientific Research Use Only, Not for Human Use.
