Product name: Lactoferrampin
Synonyms: LFampB,Lfampin, LFampin 265–284, DLIWKLLSKAQEKFGKNKSR,
Counter ion: Trifluoacetate
Format: Lyophilized powder
Description: Bovine lactoferrampin (LFampB) is an antimicrobial peptide identified through sequence analysis of bovine lactoferrin with broad range antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria as well as candidacidal activity. Lfampin comprises residues 268–284 in the N1 domain of Lf, and was found to be located in close proximity to Lfcin. As an antimicrobial peptide Lfampin plays a key role in membrane-mediated activities of Lf . Following the initial discovery of LFampin 268–284 (produced by solid-phase chemistry), a slightly longer sequence (produced by action of a single endopeptidase on bLf) was published that included an additional N-terminal helix cap region, Asp-Leu-Ile. It was found that the longer peptide LFampin 265–284 had higher activity . For both peptides, the helical conformation was found to be critical for effectiveness against Gram-positive bacteria. The sequence comparison of Lfampin from six different species shows a uniform preponderance of positively-charged residues among the hydrophobic domain containing tryptophan, a residue that is involved in membrane insertion. Lfampin exhibits broad antimicrobial action against several Gram-positive and Gram-negative bacteria, yeast and parasites.
Usage: For Scientific Research Use Only, Not for Human Use.