$ 360.0
Quantity: 1Gram
In stock
Description
Product name:γ-PGA-Trp-OMe
Catalog#: 1505501
Synonyms: γ-poly (glutamic acid)-L-tryptophan methylester,
Molecular Weight: 1,000k
Trp Content: NLT10.0%
Loss on drying: NMT10.0%
Heavy metals: NMT20ppm
Format: Hygroscopic, white to slight yellow solid
Description: Hydrophobic amino acid l-tryptophan methylester (Trp) can be grafted to γ-PGA in order to form self-assembled nanoparticles. Nanoparticles were obtained using the precipitation and dialysis methods. However, the authors found that γ-PGA-Trp NPs could not be redispersed in phosphate buffer saline (PBS) after lyophilisation by freeze drying. All sizes of γ-PGA-Trp NPs aggregated and formed relatively large NPs when dispersed in PBS. In contrast, freeze-dried γ-PGA-Phe NPs redispersed well in PBS and the size distribution was the same as before lyophilisation. It is believed that the difference in dispersibility of freeze-dried γ-PGA NPs in PBS may be due to the difference in hydrophobicity between Trp and Phe. Moreover, the shape of γ-PGA-Trp NPs was more uniform and spherical than γ-PGA-Phe particles, yet γ-PGA-Trp NPs had a soft and flexible morphology. The size of particles ranged from 34 to 192 nm and 58 to 292 nm in γ-PGA-Phe NPs and γ-PGA-Trp NPs, respectively, depending on the increase in the concentration of NaCl. No evidence was found for the comparison of drug encapsulation efficiency and release profiles between γ-PGA-Phe NPs and γ-PGA-Trp NPs.
Usage: For Scientific Research Use Only, Not for Human Use.
