$ 500.0
Quantity: 50 MG
Available on backorder
Description
Product name: AVGIGA
Catalog#: 1809040
Synonyms: anti-gp41 hexapeptide,
CAS NO.:
Sequence: AVGIGA
Modifications:
M.W:486.28
M.F.:C21H38N6O7
Purity: 95% by HPLC
Counter ion: Trifluoroacetate
Format: Lyophilized powder
Description: Owens and coworkers demonstrated the capacity of AVGIGA hexapeptide, identical in amino acid sequence to the gp41 N-terminus, to completely inhibit syncitium formation mediated by HIV-1 envelope glycoproteins expressed at the surface of HeLa CD4+ cells, an observation that has been reproduced in the present work. The inhibitory effect was sequence-specific and dose-dependent. These authors suggested that the inhibitors might interact with its homologous FP sequence at gp41 thereby preventing its normal fusogenic function. This suggestion was supported by later studies in model membranes by Pereira et al. which revealed that N-terminal AVGIGA hexapeptide also interfered with FP-vesicle interaction.
UniProt ID:
Usage: For Scientific Research Use Only, Not for Human Use.
