Cyclic peptide [R4W4]

$ 600.0

Quantity: 1mg

In stock


Product name: Cyclic peptide [R4W4]

Catalog#: 1399031

Synonyms: cyclo(RRRRWWWW),

Sequence: cyclo(Arg-Arg-Arg-Arg-Trp-Trp-Trp-Trp)

Modifications: head-to-tail cyclization,

M.W: 1369.60

M.F.: C68H88N24O8

Purity: 95%

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Antimicrobial peptides, a major class of antibacterial agents, share amphiphilicity and cationic structural properties with cell-penetrating peptides (CPPs). Herein, several amphiphilic cyclic CPPs and their analogues were synthesized and exhibited potent antibacterial activities against multidrug-resistant pathogens. Among all the peptides, cyclic peptide [R4W4]  showed the most potent antibacterial activity against methicillin-resistant Staphylococcus aureus [MRSA, exhibiting a minimal inhibitory concentration (MIC) of 2.67 μg/mL]. Cyclic [R4W4] and the linear counterpart R4W4 exhibited MIC values of 42.8 and 21.7 μg/mL, respectively, against Pseudomonas aeruginosa.


Usage: For Scientific Research Use Only, Not for Human Use.