Product name: Endothelin-1
Synonyms: ET-1,Endothelin 1,CSCSSLMDKECVYFCHLDIIW,
CAS NO.: 117399-94-7
Sequence: Cys-Ser-Cys-Ser-Ser-Leu-Met- Asp-Lys-Glu-Cys-Val-Tyr-Phe- Cys-His-Leu-Asp-Ile-Ile-Trp
Counter ion: Trifluoacetate
Format: Lyophilized powder
Description: The ET family comprises three 21-amino acid peptides (ET-1, ET-2, and ET-3) of which ET-1 is the most biologically relevant to kidney function in health and disease. ET-1 promotes cell proliferation, hypertrophy, inflammation and extracellular matrix accumulation, all of which are important factors in progression of chronic kidney disease (CKD). Renal ET-1 production increases in conditions associated with renal disease progression, such as diabetes, insulin resistance, obesity, immune system activation, dyslipidemia, reactive oxygen species formation, nitric oxide deficiency and others.Endothelin-1 also increases formation of other vasoconstrictors and growth factors (such as angiotensin II). In turn, angiotensin II activates renal ET-1 formation, thereby creating a positive feedback loop.
Uniprot ID: P05305
Usage: For Scientific Research Use Only, Not for Human Use.