Quantity: 50mg

SKU: 1101024 Category: Tag:


Product name: ETWW

Catalog#: 1101024

Synonyms: (S)-4-amino-5-(((2S,3R)-1-(((S)-1-(((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-5-oxopentanoic acid,

Sequence: Glu-Thr-Trp-Trp

M.W: 620.66

M.F.: C31H36N6O8

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Identification of key amino acids is required for development of efficient cell-penetrating peptides (CPPs) and has tremendous implications in medicine. Extensive research work has enlightened us about the importance of two amino acids, arginine and tryptophan, in cell penetration. Here, we present a top-down approach to show how spatial positions of two tryptophans regulate the cellular entry and nuclear localization. This enables us to develop short, non-toxic tetrapeptides with excellent potential for cell penetration and nuclear localization. Among them, Glu-Thr-Trp-Trp (ETWW) emerges as the most promising.


Usage: For Scientific Research Use Only, Not for Human Use.


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