Product name: Fmoc-Arg(Me)2-OH (asymmetrical)
Synonym: Fmoc-ADMA,(2S)-5-[[amino(dimethylamino)methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid,
Catalog #: 8225016
CAS No.: 268564-10-9
Molecular Formula: C23H28N4O4
Molecular Weight: 424.49
Compound ID: 46737315
Description: Asymmetric dimethylarginine (ADMA), an endogenous methylated form of the amino acid l-arginine, inhibits the activity of the enzyme endothelial nitric oxide synthase (eNOS), with consequent reduced synthesis of nitric oxide (NO). An increased synthesis and/or a reduced catabolism of ADMA might contribute to the onset and progression of atherosclerosis and thrombosis. The detrimental effects of ADMA on endothelial function, cardiovascular homeostasis, and cardiovascular outcomes have been extensively investigated.