Product name: Fmoc-Arg(Me)2-OH (symmetrical)
Synonym: Fmoc-SDMA,(2S)-5-[(N,N’-dimethylcarbamimidoyl)amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid,
Catalog #: 8225015
CAS No.: 823780-66-1
Molecular Formula: C23H28N4O4
Molecular Weight: 424.49
Compound ID: 46737316
Description: SDMA is an independent predictor of total mortality after acute stroke irrespective of renal function. SDMA is associated with atrial fibrillation, endothelial and platelet activation, and may therefore play a previously unknown role in the pathophysiology of stroke.Symmetric dimethylarginine (SDMA) is considered as a parameter for renal insufficiency superior to the established creatinine. Fmoc-based solid-phase peptide synthesis was used to prepare peptides containing a symmetrically dimethylated arginine (sDMA) residue.2.5 equiv of Fmoc-sDMA was activated with 2.38 equiv of 0.5 M HBTU in DMF and 5 equiv DIEA and added to the resin for 30 min.