$ 180.0

Quantity: 10 G

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SKU: 8144013 Category:


Product name: Fmoc-D-Asn(Trt)-OH

Synonym: N-Fmoc-N’-trityl-D-asparagine, N-(9-Fluorenylmethyloxycarbonyl)-N’-trityl-D-asparagine,

Catalog #: 8144013

Purity: 95%

CAS No.: 180570-71-2

Molecular Formula: C38H32N2O5

Molecular Weight: 596.671

Compound ID:

Description:TFA deprotection of trityl-protected N-terminal asparagine is incomplete under normal conditions, resulting in low yields or impure products. This phenomenon does not occur if the asparagine is internal, nor for trityl-protected N-terminal glutamine. Studies on the deprotection of H Asn(Trt)OH show that the incomplete deprotection is due to the extremely slow removal of a trityl group close to an amino group. The use of the new methyl-trityl protecting group overcomes this problem resulting in rapid and complete deprotection.During the Fmoc solid-phase synthesis of reduced peptide bond analogues, we observed that the trityl protection of an asparagine residue in the vicinity of a reduced peptide bond is not cleaved completely after the final trifluoroacetic acid deprotection step.

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