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Product name: Fmoc-Tyr(SO3DCV)-OH·DCHA
Synonyms: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((((2,2-dichlorovinyl)oxy)sulfonyl)oxy)phenyl)propanoic acid,
Catalog #: 8127004
Molecular Formula: C38H44Cl2N2O8S
Molecular Weight: 759.74
Tyrosine (Tyr) sulfation is a common post-translational modification that is implicated in a variety of important biological processes, including the fusion and entry of human immunodeficiency virus type-1 (HIV-1). sTyr peptides containing Met or Trp residues can be readily prepared using Fmoc-Tyr(SO3DCV)-OH. Removing the DCV groups at the end of the syntheses was readily achieved by subjecting crude peptides to 50%w/w of Pd(OH)2 in presence of Et3N (17 Eq), and H2 (balloon pressure) in water : methanol (1 : 1) for 24 h.hydrogenolysis without any reduction of Trp. The presence of Met was found not to interfere with the removal of the DCV group.
API: Ceruletide, Sincalide