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Quantity: 50 MG

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SKU: 1808213 Categories: ,


Product name: GVS-111

Catalog#: 1808213

Synonyms: ethyl phenylacetyl-Pro-Gly,N -phenylacetyl- L -prolylglycine ethyl ester,ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate,

CAS NO.: 157115-85-0

Sequence: ethyl phenylacetyl-Pro-Gly

M.W: C17H22N2O4

M.F.: 318.37

Purity: 98% by HPLC

Format: White powder

Description: GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action. GVS-111 exhibited significantly higher neuroprotection compared to the standard cognition enhancer Piracetam, or to the antioxidants Vitamin E, propyl gallate and N-tert-butyl-2-sulpho-phenylnitrone (s-PBN). In DS cortical cultures, chronic treatment with GVS-111 significantly reduced the appearance of degenerative changes and enhanced neuronal survival. The results suggest that the neuroprotective effect of GVS-111 against oxidative damage and its potential nootropic activity may present a valuable therapeutic combination for the treatment of mental retardation and chronic neurodegenerative disorders.

Compound ID: 180496


Usage: For Scientific Research Use Only, Not for Human Use.