Quantity: 50 MG
Available on backorder
Product name: GVS-111
Synonyms: ethyl phenylacetyl-Pro-Gly,N -phenylacetyl- L -prolylglycine ethyl ester,ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate,
CAS NO.: 157115-85-0
Sequence: ethyl phenylacetyl-Pro-Gly
Purity: 98% by HPLC
Format: White powder
Description: GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), suggesting an antioxidant mechanism of action. GVS-111 exhibited significantly higher neuroprotection compared to the standard cognition enhancer Piracetam, or to the antioxidants Vitamin E, propyl gallate and N-tert-butyl-2-sulpho-phenylnitrone (s-PBN). In DS cortical cultures, chronic treatment with GVS-111 significantly reduced the appearance of degenerative changes and enhanced neuronal survival. The results suggest that the neuroprotective effect of GVS-111 against oxidative damage and its potential nootropic activity may present a valuable therapeutic combination for the treatment of mental retardation and chronic neurodegenerative disorders.
Compound ID: 180496
Usage: For Scientific Research Use Only, Not for Human Use.