Humanin

Description

Product name: Humanin

Catalog#: 1201001

Organism: Human

Synonyms: Putative humanin peptide,1-24-Protein humanin (human),formyl humanin,Protein Humanin (human), MAPRGFSCLLLLTSEIDLPVKRRA,

CAS NO.: 330936-69-1

Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

M.W: C119H204N34O32S2

M.F.: 2687.23

Purity: 95%

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Humanin (HN) is 24-amino acid mitochondria-associated peptide. Since its initial discovery over a decade ago, a role for HN has been reported in many biological processes such as apoptosis, cell survival, substrate metabolism, inflammatory response, and response to stressors such as oxidative stress, ischemia, and starvation. HN and its potent analogs have been shown to have beneficial effects in many age-related diseases including Alzheimer’s disease, stroke, diabetes, myocardial ischemia and reperfusion, atherosclerosis, amyotrophic lateral sclerosis, and certain types of cancer both in vitro and in vivo. More recently, an association between HN levels, growth hormone/insulin-like growth factor-1 (GH/IGF axis), and life span was demonstrated using various mouse models with mutations in the GH/IGF axis. The goal of this review is to summarize the current understanding of the role of HN in aging and age-related diseases.

Uniprot ID: Q8IVG9

Compound ID: 16131438

 

Usage: For Scientific Research Use Only, Not for Human Use.