$ 350.0
Quantity: 10 MG
In stock
Description
Product name: Kisspeptin-10
Catalog#: 1286104
Organism: Human
Synonyms: KP10, KP-10,YNWNSFGLRF-amide,
Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Modifications: C-terminal amide,
M.W: 1302.46
M.F.: C63H83N17O14
Purity: 95%
Counter ion: Trifluoacetate
Format: Lyophilized powder
Description: Embryonic stem cells (ESCs) have enormous potential as novel cell-based therapies, but their effectiveness depends on stem cell differentiation and specific signaling regulators, which remain poorly understood. In this study, a kisspeptin peptide (KP-10) was used at different dosages to determine whether rhesus macaque-derived tau GFP-Lyon ES cells underwent kisspeptin-specific neuronal differentiation. It was found that KP-10 exhibited an anti-proliferative effect on the cells and led to morphological changes and cellular differentiation consistent with neuronal stem cell (NSC) development. The cells differentiated into Gonadotrophin Releasing Hormone (GnRH) neuronal-like cell types in response to the KP-10 treatment. There has been a previously observed connection between kisspeptin signaling, GnRH neurons and their dysfunction found in congenital disorders like idiopathic hypogonadotropic hypogonadism (IHH). Although therapeutics are a still a far-off goal, the formation and development of GnRH-positive neuronal-like cells following the application of KP-10 to Lyon NSC cells opens the door for future NSC-based therapies to treat specific reproductive disorders.
Uniprot ID: Q15726
Compoud ID: 25240297
Usage: For Scientific Research Use Only, Not for Human Use.
