Linaclotide

Description

Product name: Linaclotide

Catalog#: 2220003

Synonyms: MD-1100,

CAS NO.: 851199-59-2

Sequence: CCEYCCNPACTGCY

Modifications: Disulfide(1-6,2-10,5-13)

M.W: 1526.74

M.F.: C59H79N15O21S6

Purity: 95% by HPLC

Counter ion: Acetate

Format: Lyophilized powder

Description: Linaclotide, a 14-amino acid synthetic peptide, is a first-in-class, high-affinity guanylate cyclase C agonist (GCCA)  that is homologous to the paracrine peptide hormones guanylin and uroguanylin, i.e. the endogenous activators of guanylate cyclase C (GC-C). Linaclotide has been shown to be stable under in vitro conditions mimicking the gastric environment, i.e. exposure to a highly acidic pH and gastric hydrolases. After oral administration, linaclotide is metabolised in the small intestine to an active metabolite, a 13-amino acid peptide that retains linaclotide’s pharmacological activity.

Compound ID: 16158208

 

Usage: For Scientific Research Use Only, Not for Human Use.