$ 150.0

Quantity: 50 MG

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SKU: 1808217 Categories: ,


Product name: Livagen

Catalog#: 1808217

Synonyms: Lys-Glu-Asp-Ala


Sequence: Lys-Glu-Asp-Ala

M.W: C18H31N5O9

M.F.: 461.47

Purity: 95% by HPLC

Format: White powder

Description: It is stated that Livagen (Lys-Glu-Asp-Ala) is a weakly hydrolyzed peptide. Peptide hydrolases of small intestine do not hydrolyze Livagen even to a small extent. Under in vitro conditions Livagen reduces glycil-L-leucinedipeptidase activity in small intestine by 50%.Livagen induced activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin, and release of genes repressed due to age-related condensation of euchromatic regions in chromosomes. Our results indicate that Livagen causes de-heterochromatinization (activation) of chromatin, which is realized via modification of heterochromatin and heterochromatinized regions in chromosomes from old people.Livagen proved to be more efficient also as compared to well-known peptidase inhibitors such as puromycin, leupeptin, and D-PAM. The dose-inhibitory effect curves for Livagen and Epitalon were plotted; their IC50 equaled 20 and 500 microM, respectively.

Compound ID:


Usage: For Scientific Research Use Only, Not for Human Use.