$ 950.0

Quantity: 500 mg

In stock


Product name: Mu-Conotoxin

Catalog#: 1801201

Synonyms: μ-Conotoxin Cn IIIC; XEP-018


CAS: 936616-33-0

M.W: 2375.7

M.F.: C92H139N35O28S6

Purity: 98.5%

Active peptide assay : 50ppm

Solubility:  Water

pH: 5-7

Format: Clear cololess solution

Description: Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin blocks both voltage-gated sodium channels and nicotinic acetylcholine receptor (nAChR). Inhibits the skeletal muscle rNav1.4/SCN4A (IC50=1.3 nM) and the brain rNav1.2/SCN2A in a long-lasting manner. A low inhibition is also observed on neuronal mNav1.6/SCN8A and mNav1.7/SCN9A. Modestly blocks nAChR alpha-3/beta-2 subtype (IC50=450 nM) (partially reversible) and, to a lesser extent, alpha-7 and alpha-4/beta-2 subtypes (reversible). In vitro, decreases twitch tension in mouse hemidiaphragms (IC50=150 nM), and displays a high blocking effect in mouse extensor digitorum longus muscles (IC50=46 nM).

Usage: For Scientific Research Use Only, Not for Human Use.