Quantity: 50 MG
Available on backorder
Product name: Nej1 (331–334)
Synonyms: nuclear localization signal (NLS) , hydrophobic patch,
Purity: 95% by HPLC
Counter ion: Trifluoacetate
Format: Lyophilized powder
Description: Nej1 is an essential factor in the non-homologous end-joining (NHEJ) pathway and interacts with the DNA ligase complex, Lif1-Dnl4, through interactions with Lif1. We have mapped K331-V338 in the C-terminal region of Nej1 to be critical for its functionality during repair. Truncation and alanine scanning mutagenesis have been used to identify a motif in Nej1, KKRK (331–334), which is important for both nuclear targeting and NHEJ repair after localization.
Usage: For Scientific Research Use Only, Not for Human Use.