Nisin

Description

Product name: Nisin

Catalog#: 1381007

Organism: Streptococcus lactis

Synonyms: Streptococcus lactic peptide,

CAS NO.: 1414-45-5

Sequence: Ile-Dhb-(Ser-Ile-Dha-Leu-Cys)-(Abu-Pro-Gly-Cys)-Lys-(Abu-Gly-Ala-Leu-Met-Gly-Cys)-Asn-Met-Lys-(Abu-Ala-[Abu-Cys)-His-Cys]-Ser-Ile-His-Val-Dha-Lys

Modifications: (Z)-2,3-didehydrobutyrine(Dhb2),Lanthionine (Ser3-Cys7),2,3-didehydroalanine(Dha5),Beta-methyllanthionine(Thr8-Cys11),Beta-methyllanthionine(Thr13-Cys19),Beta-methyllanthionine(Thr23-Cys26),Beta-methyllanthionine(Thr25-Cys28), 2,3-didehydroalanine(Dha33),

M.W: 3354.09

M.F.: C143H230N42O37S7

Purity: 95%

Format: White powder

Description: Nisin is the first, and so far only lantibiotic to have found commercial use. Discovered in 1928, it exhibits a broad spectrum of inhibition against Gram positive bacteria including spoilage and food-borne pathogens such as staphylococci, bacilli, clostridia and Listeria. Nisin has been extensively used in the food industry as a food preservative for decades gaining both EU (E234) and Food and Drug Administration (FDA) approval and has been employed in a wide variety of foods. Nisin acts by altering the integrity of the cellular membrane and forming short-lived pores, thereby changing the membrane potential. Nisin becomes immersed in the cell membrane through the cationic portions of the amino acids extending to one side of the molecule. These cationic portions interact with the negatively charged phospholipid heads, while the hydrophobic portion of nisin interacts with the membrane core. Nisin’s involvement with the membrane, therefore, mediates phospholipid reorganization and allows for an influx of ions. Nisin is known to preferentially interact with phosphatidylcholine.

 

Usage: For Scientific Research Use Only, Not for Human Use.