Product name: Peptide 1018
Synonyms: Innate defense regulator peptide-1018 (IDR-1018), VRLIVAVRIWRR-NH2,
Counter ion: Trifluoacetate
Format: Lyophilized powder
Description: Innate defense regulator peptide-1018 (IDR-1018) is a synthetic 12-amino acid derivative of bactenecin, a bovine Host-defense peptide (HDP). IDR-1018 can directly kill bacteria, can modulate differentiation and activation of macrophages and neutrophils, thereby regulating their production of chemokines and cytokines, can reduce soft tissue infections, and can disrupt bacterial biofilms. IDR-1018 is a broad-spectrum anti-biofilm peptide that acts by binding to and causing the degradation of the widespread signaling nucleotide (p)ppGpp, which is involved in stress responses and biofilm formation. Peptide 1018 exhibited modest antimicrobial activity against planktonic cells, but at concentrations well below the MIC, it completely prevented biofilm formation and eradicated preformed mature biofilms caused by both Gram-negative and Gram-positive bacterial pathogens. Dispersal of biofilms was observed after treatment with 0.8 μg/ml of peptide, while biofilm cells were almost completely killed at higher concentrations of peptide (10 μg/ml).
Usage: For Scientific Research Use Only, Not for Human Use.